Fast Disintegrating Tablet Technology: Newly Prospects

Tablet that disintegrate rapidly in the mouth are convenient for patient who have difficulty in swallowing conventional dosages forms. Although various formulation technologies like Zydis Technology, Durasolve Technology, Orasolve Technology, Flash Dose Technology, Wow Tab Technology, Flash Tab Technology, Quicksolv Technology, Lyos Technology, Fast Melt Technology and Zip-lets Technology are used. This review highlights numerous techniques to explain the phenomenon of preparing mouth disintegration tablets like Freeze Drying, Molding, Sublimation, Spray Drying, Direct compression, Wet granulation and Dry granulation. INTRODUCTION: Recently, Pharmaceutical preparations used for elderly patients have been investigated to improve the treatment compliances and quality of life of patients . Recent advances in Novel Drug Delivery System (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is “Mouth Dissolving Tablet” 2, . The concept of Mouth Dissolving Drug Delivery System emerged from the desire to provide patient with conventional mean of taking their medication. Difficulty in swallowing (Dysphasia) is a common problem of all age groups, especially elderly and pediatrics, because of physiological changes associated with these groups of patients . Other categories that experience problems using conventional oral dosage forms includes mentally ill, uncooperative and nauseated patients, those with conditions of motion sickness, sudden episodes of allergic attack or coughing. Some times it may be difficult to swallow conventional products due to unavailability of water . These problems led to the development of novel type of solid oral dosage form called “Mouth Dissolving Tablets”. This tablet disintegrates instantaneously when placed on tongue, releasing the drug that dissolves or disperses in the saliva . On placing mouth-dissolving tablet in the mouth, saliva serves to rapidly dissolve the dosage form. The saliva containing the dissolved or dispersed medicament is then swallowed and the drug is absorbed in the normal way. Some drugs are absorbed from the mouth, pharynx and esophagus as the saliva passes down into the stomach & it may produce rapid onset of action . In such a case, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form . The dispersible tablets allows dissolution or dispersion in water prior to administration but the Mouth Dissolving Tablet instead of dissolving or disintegrating in water is expected to